RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
ATG5
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
Western Blot; qRT-PCR; Immunofluorescence etc.
Target
NA
Pathway
mTOR pathway
PubMed ID
Title
Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway
Year
2022
Function
"The analysis showed that the transcript levels of genes in the mTOR pathway, including?EIF4EBP1, MAP1LC3A?and?RPS6,?were positively correlated with fibrotic lesions. Interestingly, the transcript levels of the autophagy gene?ATG5, which is negatively regulated by mTOR, were negatively correlated with IPF."